Useful Info
Metabolism Summary   

 

 

 

A general overview of the major metabolic pathways 
 
Metabolism is the set of chemical rections that occur in a cell, which enable it to keep living, growing and dividing. Metabolic processes are usually classified as:
  • catabolism - obtaining energy and reducing power from nutrients.
  • anabolism - production of new cell components, usually through processes that require energy and reducing power obtained from nutrient catabolism.
    There is a very large number of metabolic pathways. In humans, the most important metabolic pathways are:
  • glycolysis - glucose oxidation in order to obtain ATP
  • citric acid cycle (Krebs cycle) - acetyl-CoA oxidation in order to obtain GTP and valuable intermediates.
  • oxidative phosphorylation - disposal of the electrons released by glycolysis and citric acid cycle. Much of the energy released in this process can be stored as ATP.
  • pentose phosphate pathway - synthesis of pentoses and release of the reducing power needed for anabolic reactions.
  • urea cycle - disposal of NH4+ in less toxic forms
  • fatty acid β-oxidation - fatty acids breakdown into acetyl-CoA, to be used by the Krebs cycle.
  • gluconeogenesis - glucose synthesis from smaller percursors, to be used by the brain.
  • Source.http://www2.ufp.pt/~pedros/bq/integration.htm

Source.http://images.tutorvista.com/cms/images/44/steps-involved-in-lipid-metabolism1.png

 

2=A few of the metabolic pathways present in the cell

File:Metabolism scheme.GIF

SOURCE.http://en.citizendium.org/wiki/File:Metabolism_scheme.GIF

 

Benefit of newborn screening   

Why screen your baby?





 

Disorder Screened

 

Effect if NOT SCREENED

 

Effect if SCREENED and managed

 


 

Severe Mental Retardation

 

Normal

 

CAH (Congenital Adrenal Hyperplasia)

 

Death

 

Alive and normal

 

GAL (Galactosemia)

 

Death or Cataracts

 

Alive and normal

 

PKU (Phenylketonuria)

 

Severe Mental Retardation

 

Normal

 


 

Severe Anemia, Kernicterus

 

Normal

 

Maple Syrup Urine Disorder*

 

Death

 

Alive and normal

source.http://www.newbornscreening.ph/index.php?option=com_content&view=section&id=3&layout=blog&Itemid=60

 

 


 

Dr Archibald Edward Garrod

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