There is an accelerating demographic switch from communicable diseases to genetic disorders.The expression of genetic disease is the combined effect of genes and the environment.There are 25 million births India annually; 8 lakh born with congenital malformation; 3.5 lakh swith glucose 6 phosphate deficiency (G6PD);25,000 with metabolic disorders; 20,000 withDown Syndrome, 15,000 with congenital hypothyroidism, 14,000 with thalassaemia and5,000 with sickle cell anemia.
